The DNA methylome refines clinical diagnosis and prognosis of Acute Myeloid Leukemia

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Table of Contents

Data Processing

• Discovery Dataset
• Validation Dataset
• Reclassification to Current Clinical Guidelines

AML Prognostic Model

• Epigenome Wide Association Study
• MethylScoreAML Px Development
• MethylScoreAML Px Validation

AML Diagnostic Model

• Diagnostic Classifier

Nanopore Sequencing Testing

• Applying models to Nanopore data

Benchmarks

• Dx score - various components
• Dx score - pedsAML only
• Dx score - less strict pre-processing
• Dx score - without relapse and ALL
• Dx score - without relapse